Dr. Jacob Golenser, Ph.D.
|Head of Anti-Parasitic Drugs Lab.|
||Kremsner P.G. Institute of Tropical Medicine, Tuebingen Germany, Drug effects on immune functions.
Hunt N. University of Sydney, Australia. Cerebral malaria.
||M.Sc. Microbiology, The Hebrew University of Jerusalem.
||Ph.D. Parasitology, The Hebrew University of Jerusalem.
||Senior Investigator, MRC Durban, South Africa.
||Senior Investigator in Parasitology, Faculty of Medicine, The Hebrew University of Jerusalem and The Hadassah Medical College, Jerusalem (part time).
Our studies comprise the design, production and examination of drugs against malaria and leishmaniasis, both of which have global and regional significance. Due to the international interest in these diseases we are cooperating with research groups in both technologically advanced and developing countries. Our specific expertise also involves us in general health projects related to chemotherapy (slow release of drugs, transplantation, cancer, etc.).
One of the major problems in the struggle against malaria is the dwindling arsenal of antimalarial drugs due to the evolution of drug resistance. We are thus attempting to define and validate new drug targets, produce derivatives of existing drugs, and use combinations of drugs that might be synergistic or prevent the development of resistance. The current treatment of leishmanial infections is also inadequate due to toxicity of the marketed first line drugs (pentavalent antimonials) and parasite resistance to these drugs.
Parasitic infection may be overcome by a variety of balanced immune responses. Drugs may affect the disease by reducing parasite load and by altering immune responses. We are therefore investigating drug effects on both parasites and immune functions.
The variety of techniques which have been used throughout our research with parasites are also applied in experiments concerning the treatment of melanoma, solid tumors and bone infections.
Deharo E, Barkan D, Krugliak M, Golenser J, Ginsburg H. (2003). Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels. Biochem. Pharmacol. 66: 809-817.
Ginsburg H, Golenser J. (2003). Glutathione is involved in the antimalarial action of chloroquine and its modulation affects drug sensitivity of human and murine species Plasmodium. Redox Report. 8: 276-279.
Golenser J, Domb A, Kremsner P, Luty A. (2003). Iron chelators as drugs against malaria pose a potential risk. Redox Report. 8: 268-271.
Ehrenfreund-Kleinman T, Domb A, Golenser J. (2003). Polysaccharide scaffolds prepared by crosslinking of polysaccharides with chitosan or proteins for cell growth. J Bioactive Compatible Polymers. 8: 323-338.
Ehrenfreund-Kleinman T, Golenser J, Domb A. (2004). Conjugation of amino-containing drugs to polysaccharides by tosylation: amphotericin B-arabinogalactan conjugates. Biomaterials. 25: 3049-3057.
Bekerman T, Golenser J, Domb A. (2004). Cyclosporin nanoparticulate lipospheres for oral administration. J Pharmaceutical Sci. 93: 1264-1270.
Mizrahi B, Golenser J, Wolnerman JS, Domb A. (2004). Adhesive tablet effective for treating cancer sores in human. J. Pharmaceutical Sci. 93: 2927-2935.
Ehrenfreund-Kleinman T, Domb A, Jaffe CL, Nasereddin A, Leshem B, Golenser J. (2005). The effect of Amphotericin B derivatives on Leishmania and immune functions. J. Parasitol. 91: 158-163.
Golenser J, Domb A. New formulations and derivatives of Amphotericin B for treatment of leishmaniasis. MiniRev. Med. Chem. In press.
Sokolsky-Papkov, M., Jacob Golenser, J., Domb, A. Impact of aldehyde groups on Amphotericin B-Dextran imine conjugate toxicity in vitro. Biomacromolecules. In press.
Golenser J, Abraham Domb A, Mordechai T, Benni Leshem B, Adrian Luty A, Kremsner P. Iron chelators: correlation between effects on Plasmodia and immune functions. J. Parasitol. In press.
Domb A., Teomim D., Golenser J., Langer R., Israel Z. Biodegradable polyanhydrides. In: Polymer Chemistry, Biodegradation and Toxicity (Arshady R. ed.). In press.
Ehrenfreund-Kleinman T, Golenser J, Domb A. Polysaccharides scaffolds for tissue engineering. In: Scaffolding for Tissue Engineering (Elisseeff, JH. Ed.). In press.
Golenser, J., McQuillan, J., Hee, L., Mitchell, A.J. and Hunt, N.H. Conventional and experimental treatment of cerebral malaria. Int. J. Parasitol. In press.
Golenser, J., Hunt, N.H., Sarel, S. Probing for anti-parasitic drugs. Editorial. MiniRev. Med. Chem. In press.
Hunt, N.H., Golenser, J., Chan-Ling, T., Parekh, S. Rae, C., Potter, S., Medana, I.M., Miu, J., Ball, H.J. Immunopathogenesis of cerebral malaria. Int. J. Parasitol. In press.
Selected Research Support
||Gretel B. Bloch Trust
Zelman Cowen Trust.